Navigation and service

Use of cookies

By clicking on "Allow" you consent to the anonymous recording of your stay on the site. The evaluations do not contain any personal data and are used exclusively for the analysis, maintenance and improvement of our website. For further information on data privacy, please click on the following link: Data Privacy Policy

OK

Consultant Laboratory for Noroviruses at the Robert Koch Institute

Head:
Sandra Niendorf
Deputy:
Sonja Jacobsen

Norovirus infections are recorded worldwide as the most common cause of viral gastroenteritis outbreaks. Human noroviruses are shed by infected individuals through feces and vomit. They are highly infectious and are characterized by high environmental resistance. Transmission can be caused by a smear infection (from person to person or via contaminated foods and/or water) or by virus-containing aerosols after vomiting. Norovirus infections affect all age groups, especially the elderly and children. During the winter months, norovirus infections lead to major outbreaks in community settings such as nurseries, schools, nursing homes, and hospitals. Since January 2001 infections with noroviruses must be notified according to the German Protection Against Infection Act (Infektionsschutzgesetz).

The consultant laboratory provides various molecular biological methods for the detection and characterization of noroviruses. The main task of the laboratory is molecular surveillance of norovirus outbreaks, as well as detection of molecular-epidemiological links (transmission chains). Sequencing and phylogenetic analyses can be used to make statements about evolutional dynamics and to detect new recombinants and new genotypes. These data are shared via NoroNet to provide early information on the emergence and spread of circulating variants.

The laboratory also provides support for the diagnosis of other viral gastroenteritis pathogens. For special issues molecular biological methods are available for the detection of sapovirus, astrovirus, or Aichi virus.

Address

Unit 15: Gastroenteritis and Hepatitis Pathogens and Enteroviruses
Robert Koch Institute

Seestrasse 10
13353 Berlin
Germany

Contact

Consultant Laboratory for Noroviruses
Phone:
+49 30 18754 2375
Fax:
+49 30 1810754 2617
Contact:
Consultant Laboratory for Noroviruses

Date: 26.04.2023

Publications

  • Niendorf S, Mas Marques A, Bock CT, Jacobsen S (2022): Diversity of human astroviruses in Germany 2018 and 2019
    Virology Journal 19 (1): 5. doi: 10.1186/s12985-022-01955-3. more

  • Niendorf S, Harms D, Hellendahl KF, Heuser E, Böttcher S, Bock CT, Ulrich RG (2021): Presence and diversity of different enteric viruses in wild Norway rats (Rattus norvegicus).
    Viruses 13 (6): 992. Epub May 26. doi: 10.3390/v13060992. more

  • Manouana GP, Nguema-Moure PA, Mbong Ngwese M, Bock CT, Kremsner PG, Borrmann S, Eibach D, Mordmüller B, Velavan TP, Niendorf S, Adegnika AA (2021): Genetic diversity of enteric viruses in children under five years old in Gabon.
    Viruses 13 (4): 545. Epub Mar 24. doi: 10.3390/v13040545. more

  • Niendorf S, Faber M, Tröger A, Hackler J, Jacobsen S (2020): Diversity of noroviruses throughout outbreaks in Germany 2018.
    Viruses 12 (10): 1157. Epub Oct 13. doi: 10.3390/v12101157. more

  • Niendorf S, Faber M, Tröger A, Noack C, Jacobsen S (2020): Norovirus-Infektionen in Deutschland, ein Rückblick auf das Jahr 2019.
    Epid Bull (24): 3–9. doi: 10.25646/6885. more

  • Koukou G, Niendorf S, Hornei B, Schlump JU, Jenke AC, Jacobsen S (2019): Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report.
    J. Med. Case Rep. 13 (1): 341. Epub Nov 23. doi: 10.1186/s13256-019-2302-6. more

  • Jacobsen S, Höhne M, Mas Marques A, Beslmüller K, Bock CT, Niendorf S (2018): Co-circulation of classic and novel astrovirus strains in patients with acute gastroenteritis in Germany
    J. Infect. 76 (5): 457-464. Epub Feb 14. doi: 10.1016/j.jinf.2018.02.006. more

  • van Beek J, de Graaf M, Al-Hello H, Allen DJ, Ambert-Balay K, Botteldoorn N, Brytting M, Buesa J, Cabrerizo M, Chan M, Cloak F, di Bartolo I, Guix S, Hewitt J, Iritani N, Jin M, Johne R, Lederer I, Mans J, Martella V, Maunula L, McAllister G, Niendorf S et al.; on behalf of NoroNet (2018): Molecular surveillance of norovirus, 2005–16: an epidemiological analysis of data collected from the NoroNet network
    Lancet Infect. Dis. 18 (5): 545-553. Epub Jan 26. doi: 10.1016/S1473-3099(18)30059-8. more

Additional Information

Accreditation

Selected methods are
accredited to DIN EN ISO 15189 and
DIN EN ISO/IEC 17025
by Dakks

Accreditation  Selected methods are accredited by Dakks