Porstmann AU, Marcus U, Pleyer U (2002): Syphiliserstdiagnose durch den Augenarzt. [Primary diagnosis of syphilis by the ophthalmologist]
Klin. Monatsbl. Augenheilkd. 219 (5): 349-352.

BACKGROUND: Throughout the developed world the reported incidence of sexually transmitted diseases is rising with previously unreported cases at rates of 40-70 %. According to German sources, recent epidemiological data show a considerable increase of syphilis especially among homosexual men in larger cities. PATIENTS: We report on 4 patients (age 38-54) who were referred to our outpatient department because of vision loss of unknown origin. All were subsequently tested positive for syphilis. None of the patients (3 men, 1 woman) belonged to a risk group, only one described systemic symptoms (urethritis and arthritis). The ocular manifestations of syphilis were broad: granulomatous and non-granulomatous anterior uveitis, papillitis, and chorioretinitis. Two patients also tested positive for HIV. After systemic antibiotic therapy, the ocular diseases stabilized. CONCLUSION: Diagnosis and therapy of syphilis is cost-effective. The rise of syphilis especially in urban areas necessitates a high level of suspicion dealing with patients with intraocular inflammation of unknown origin. Lues serology should be incorporated into routine lab diagnostics to aid in the detection of such cases.