Hoenen T, Kolesnikova L, Becker S (2007): Recent advances in filovirus- and arenavirus-like particles
Future Virol. 2 (2): 193-203.

Both filoviruses and arenaviruses are enveloped viruses with a single-stranded RNA genome. Most human pathogenic arenaviruses, as well as filoviruses, cause severe hemorrhagic fevers with a high rate of case fatalities. Increasing numbers of outbreaks, the possibility of imported infections and the potential use of these viruses as bioterrorism agents have led to increased interest in these viruses and their biology. Virus-like particles are excellent tools to study the life-cycle of filoviruses and arenaviruses and have demonstrated the potential for use as safe and effective vaccines. This review summarizes the recent advances in the production, study and application of filovirus- and arenavirus-like particles, and provides an outlook on possible future directions for research into these viruses using virus-like particles.