Chen T, Jansen L, Gondos A et al., Gekid Cancer Survival Working Group (for RKI Kraywinkel K) (2012): Survival of cervical cancer patients in Germany in the early 21st century: A period analysis by age, histology, and stage
Acta Oncol. 51 (7): 915–921.

Purpose. Population-based studies on cervical cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for cervical cancer patients in Germany. Methods. We used a pooled German national dataset including data from 11 cancer registries covering a population of 33 million people. Included were 15 685 patients diagnosed with cervical cancer from 1997 to 2006. Period analysis was performed to calculate the five-year relative survival (RS) 2002–2006. Trends in survival between 2002 and 2006 were examined using model-based period analysis. Age-adjustment was done using five age groups (15–44, 45–54, 55–64, 65–74, and 75 + years). Results. Overall, age-adjusted five-year relative survival in 2002–2006 was 64.7%. A strong age gradient was observed, with five-year RS decreasing from 81.7% in age group 15–49 years to 46.3% in age group 70 + years. Prognosis furthermore strongly varied by stage, with age-adjusted five-year RS reaching 84.6% for localized, 48.2% for regional, and 17.9% for distant stage. From 2002 to 2006, a significant improvement (4.7 percent units) in overall age-adjusted five-year RS was seen. The improvement was most pronounced for age groups 55–64 years (from 54.2 to 65.6%) and 65–74 years (from 50.0 to 58.1%). Conclusion. In this first comprehensive population-based study from Germany, prognosis of cervical cancer strongly varied by age and stage. Prognosis continued to improve, in particular in age range 55–74 years, in the five-year period assessed.